Pain sensation

Pain is induced by mechanical damage of tissue cells.
•As a result of damage bradykinin like peptides are released.
•These peptides lead to the stimulation of IV type afferent fibers in the region
Pain sensation is transmitted to the brain by anterolateral pathway.
•The type IV afferents synapse on the neuron in lamina I and IV region of spinal gray matter.
•These second order neuron are inhibited by somatosensoric large afferent fibers.

•That is why the pain sense can be decreased by mechanical stimuli applied from same dermatomal region of pain.