H. Blood-Brain Barrier: Nerve tissue of the CNS receives oxygen and nutrients from capillaries in the pia mater. These capillaries are relatively impermeable because (1) their endothelial cells lack fenestrations and are joined at their borders by tight junctions, and (2) they are partly surrounded by the cytoplasmic processes of neuroglia called astrocytes. These features contribute to a structural and functional barrier that protects CNS neurons from many extraneous influences and prevents certain antibiotics and chemotherapeutic agents from reaching the CNS.
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